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[Factors involved in host-pathogen interaction for the risk of Hodgkin lymphoma induced by Epstein Barr virus].
[hodgkin lymphoma, classical]
Hodgkin
lymphoma
(
HL
)
is
a
neoplasm
characterized
by
malignant
cells
called
Reed
Sternberg
and
Hodgkin
's
cells
in
the
lymphatic
system
.
Such
cells
comprise
1
%
of
the
tumor
while
the
remainder
is
made
up
of
lymphocytes
,
histiocytes
,
eosinophils
and
plasma
non-neoplastic
cells
.
The
annual
global
incidence
of
HL
is
3
-
10
/
100
,
000
inhabitants
and
is
most
commonly
found
in
young
adults
.
The
mechanism
by
which
cell
transformation
is
accomplished
is
not
entirely
clear
;
however
,
some
evidences
suggest
that
oncogenic
viruses
like
the
Epstein
Barr
virus
(
EBV
)
may
have
a
high
impact
on
the
pathogenesis
of
lymphoproliferation
.
Genetic
and
environmental
factors
could
be
involved
,
since
it
has
been
found
a
high
incidence
of
HL
among
members
of
the
same
family
.
In
Mexico
,
there
have
been
studies
to
determine
the
prevalence
of
EBV
in
patients
with
HL
and
found
the
presence
of
this
virus
in
up
to
64
.
2
%
of
the
cases
.
EBV
has
been
detected
in
the
Reed
Sternberg
cells
and
Hodgkin
cells
in
50
%
of
cases
of
classical
HL
.
There
is
not
a
satisfactory
explanation
for
this
,
but
it
has
been
proposed
that
geographic
and
immunological
variabilities
play
a
role
in
the
positivity
of
EBV
in
HL
.
However
,
despite
recent
advances
in
the
field
,
there
is
insufficient
evidence
to
show
a
clear
association
between
host
factors
,
environment
and
pathogens
,
and
the
risk
of
lymphoproliferation
leading
to
the
development
of
HL
.
This
review
aims
to
give
an
overview
about
the
risk
factors
that
influence
the
interaction
of
host
,
pathogens
and
environment
in
the
etiology
of
HL
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated