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[Factors involved in host-pathogen interaction for the risk of Hodgkin lymphoma induced by Epstein Barr virus].
[hodgkin lymphoma, classical]
Hodgkin
lymphoma
(
HL
)
is
a
neoplasm
characterized
by
malignant
cells
called
Reed
Sternberg
and
Hodgkin
's
cells
in
the
lymphatic
system
.
Such
cells
comprise
1
%
of
the
tumor
while
the
remainder
is
made
up
of
lymphocytes
,
histiocytes
,
eosinophils
and
plasma
non-neoplastic
cells
.
The
annual
global
incidence
of
HL
is
3
-
10
/
100
,
000
inhabitants
and
is
most
commonly
found
in
young
adults
.
The
mechanism
by
which
cell
transformation
is
accomplished
is
not
entirely
clear
;
however
,
some
evidences
suggest
that
oncogenic
viruses
like
the
Epstein
Barr
virus
(
EBV
)
may
have
a
high
impact
on
the
pathogenesis
of
lymphoproliferation
.
Genetic
and
environmental
factors
could
be
involved
,
since
it
has
been
found
a
high
incidence
of
HL
among
members
of
the
same
family
.
In
Mexico
,
there
have
been
studies
to
determine
the
prevalence
of
EBV
in
patients
with
HL
and
found
the
presence
of
this
virus
in
up
to
64
.
2
%
of
the
cases
.
EBV
has
been
detected
in
the
Reed
Sternberg
cells
and
Hodgkin
cells
in
50
%
of
cases
of
classical
HL
.
There
is
not
a
satisfactory
explanation
for
this
,
but
it
has
been
proposed
that
geographic
and
immunological
variabilities
play
a
role
in
the
positivity
of
EBV
in
HL
.
However
,
despite
recent
advances
in
the
field
,
there
is
insufficient
evidence
to
show
a
clear
association
between
host
factors
,
environment
and
pathogens
,
and
the
risk
of
lymphoproliferation
leading
to
the
development
of
HL
.
This
review
aims
to
give
an
overview
about
the
risk
factors
that
influence
the
interaction
of
host
,
pathogens
and
environment
in
the
etiology
of
HL
.
Diseases
Validation
Diseases presenting
"the development of hl"
symptom
hodgkin lymphoma, classical
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