Impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography staging in newly diagnosed classical Hodgkin lymphoma: fewer cases with stage I disease and more with skeletal involvement.

[hodgkin lymphoma, classical]

(18 )F-Fluorodeoxyglucose positron emission tomography / computed tomography (PET /CT ) is a highly accurate staging method in classical Hodgkin lymphoma (cHL ). We retrospectively compared the staging results obtained in two large cohorts of patients with cHL diagnosed before (n = 324 ) and after (n = 406 ) the introduction of PET /CT staging in a retrospective study . In PET /CT staged patients , stage I disease was less frequent (16 % vs . 27 %, p < 0 .001 ) while stage IV disease was more frequent (17 % vs . 10 %, p = 0 .02 ). Imaging-detected skeletal involvement was recognized more often in PET /CT staged patients (17 % vs . 2 %, p < 0 .001 ), and the presence of focal skeletal PET /CT lesions was associated with higher risk of progression (hazard ratio [HR ] 1 .96 , 95 % confidence interval [CI ]: 1 .14 -3 .36 ). The German Hodgkin Study Group (GHSG ) risk classification (early , intermediate , advanced disease ) predicted outcome in PET /CT staged patients . In conclusion , PET /CT led to higher disease stages , and the more frequently diagnosed skeletal lesions may be an adverse prognostic factor .

Diseases
Validation

Diseases presenting "advanced disease" symptom

adrenomyeloneuropathy

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

dedifferentiated liposarcoma

esophageal squamous cell carcinoma

fabry disease

hodgkin lymphoma, classical

primary effusion lymphoma

primary hyperoxaluria type 1

systemic capillary leak syndrome

well-differentiated liposarcoma

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