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CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Recent
studies
have
reported
the
prognostic
value
of
tissue-associated
magrophages
(
TAMs
)
in
classical
Hodgkin
lymphoma
(
cHL
)
.
In
addition
,
TAMs
are
implicated
in
the
tumor
angiogenesis
.
In
this
study
,
we
examined
the
prognostic
relevance
of
TAMs
in
relation
to
vascular
endothelial
growth
factor
(
VEGF
)
expression
and
angiogenesis
in
uniformly
treated
cases
of
cHL
.
Diagnostic
tissue
from
116
patients
with
ABVD-treated
cHL
was
evaluated
retrospectively
by
immunohistochemical
analysis
for
CD
68
,
CD
163
and
VEGF
expression
and
for
CD
31
expression
as
a
measure
of
microvessel
density
(
MVD
)
.
High
CD
163
expression
(
≥
35
%
of
cellularity
)
correlated
with
VEGF
expression
(
Pearson
's
Chi
-square
test
,
P
=
0
.
008
)
and
MVD
(
Spearman
correlation
coefficient
0
.
310
,
P
<
0
.
001
)
.
High
CD
163
expression
was
associated
with
inferior
event-free
survival
(
EFS
,
P
=
0
.
005
)
and
overall
survival
(
OS
,
P
<
0
.
001
)
in
univariate
analysis
.
In
multivariate
analysis
,
high
CD
163
expression
was
strongly
associated
with
inferior
EFS
(
P
=
0
.
043
)
and
OS
(
P
=
0
.
008
)
.
Patients
with
high
MVD
had
a
lower
OS
than
those
with
low
MVD
,
but
the
difference
was
not
significant
(
P
=
0
.
071
,
respectively
)
.
While
high
expression
of
CD
68
was
also
associated
with
inferior
EFS
(
P
=
0
.
007
)
,
it
showed
no
correlation
with
VEGF
or
MVD
.
O
ur
data
confirms
that
CD
163
expression
provides
independent
prognostic
information
in
cHL
.
The
correlation
of
CD
163
with
VEGF
expression
and
MVD
suggests
the
role
of
CD
163
-
positive
cells
in
tumor
angiogenesis
of
cHL
.
Diseases
Validation
Diseases presenting
"growth factor"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
aniridia
cadasil
cholangiocarcinoma
coats disease
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
holt-oram syndrome
inclusion body myositis
kallmann syndrome
krabbe disease
liposarcoma
lymphangioleiomyomatosis
oculocutaneous albinism
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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