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CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Recent
studies
have
reported
the
prognostic
value
of
tissue-associated
magrophages
(
TAMs
)
in
classical
Hodgkin
lymphoma
(
cHL
)
.
In
addition
,
TAMs
are
implicated
in
the
tumor
angiogenesis
.
In
this
study
,
we
examined
the
prognostic
relevance
of
TAMs
in
relation
to
vascular
endothelial
growth
factor
(
VEGF
)
expression
and
angiogenesis
in
uniformly
treated
cases
of
cHL
.
Diagnostic
tissue
from
116
patients
with
ABVD-treated
cHL
was
evaluated
retrospectively
by
immunohistochemical
analysis
for
CD
68
,
CD
163
and
VEGF
expression
and
for
CD
31
expression
as
a
measure
of
microvessel
density
(
MVD
)
.
High
CD
163
expression
(
≥
35
%
of
cellularity
)
correlated
with
VEGF
expression
(
Pearson
's
Chi
-square
test
,
P
=
0
.
008
)
and
MVD
(
Spearman
correlation
coefficient
0
.
310
,
P
<
0
.
001
)
.
High
CD
163
expression
was
associated
with
inferior
event-free
survival
(
EFS
,
P
=
0
.
005
)
and
overall
survival
(
OS
,
P
<
0
.
001
)
in
univariate
analysis
.
In
multivariate
analysis
,
high
CD
163
expression
was
strongly
associated
with
inferior
EFS
(
P
=
0
.
043
)
and
OS
(
P
=
0
.
008
)
.
Patients
with
high
MVD
had
a
lower
OS
than
those
with
low
MVD
,
but
the
difference
was
not
significant
(
P
=
0
.
071
,
respectively
)
.
While
high
expression
of
CD
68
was
also
associated
with
inferior
EFS
(
P
=
0
.
007
)
,
it
showed
no
correlation
with
VEGF
or
MVD
.
O
ur
data
confirms
that
CD
163
expression
provides
independent
prognostic
information
in
cHL
.
The
correlation
of
CD
163
with
VEGF
expression
and
MVD
suggests
the
role
of
CD
163
-
positive
cells
in
tumor
angiogenesis
of
cHL
.
Diseases
Validation
Diseases presenting
"inferior efs"
symptom
hodgkin lymphoma, classical
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