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Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
interaction
between
the
tumor
cells
in
classical
Hodgkin
lymphoma
(
cHL
)
and
the
microenvironment
includes
aberrant
activity
of
receptor
tyrosine
kinases
.
In
this
study
we
evaluated
the
expression
,
functionality
and
prognostic
significance
of
Insulin
-like
growth
factor
-
1
receptor
(
IGF-
1
R
)
in
cHL
.
IGF-
1
R
was
overexpressed
in
55
%
(
44
/
80
)
of
cHL
patients
.
Phosphorylated
IGF-
1
R
was
detectable
in
a
minority
of
the
IGF-
1
R
positive
tumor
cells
.
The
overall
survival
(
OS
,
98
%
)
and
5
-
year
progression-free
survival
(
PFS
,
93
%
)
was
significantly
higher
in
IGF-
1
R
positive
cHL
patients
compared
to
IGF-
1
R
negative
patients
(
OS
83
%
,
p
=
 
.
029
and
PFS
77
%
,
p
=
 
.
047
,
respectively
)
.
Three
cHL
cell
lines
showed
expression
of
IGF-
1
R
,
with
strong
staining
especially
in
the
mitotic
cells
and
expression
of
IGF-
1
.
IGF-
1
treatment
had
a
prominent
effect
on
the
cell
growth
of
L
428
and
L
1236
cells
and
resulted
in
an
increased
phosphorylation
of
IGF
1
R
,
Akt
and
ERK
.
Inhibition
of
IGF-
1
R
with
cyclolignan
picropodophyllin
(
PPP
)
decreased
cell
growth
and
induced
a
G
2
/
M
cell
cycle
arrest
in
all
three
cell
lines
.
Moreover
,
a
decrease
in
pCcd
2
and
an
increase
in
CyclinB
1
levels
were
observed
which
is
consistent
with
the
G
2
/
M
cell
cycle
arrest
.
In
conclusion
,
IGF-
1
R
expression
in
HRS
cells
predicts
a
favorable
outcome
,
despite
the
oncogenic
effect
of
IGF-
1
R
in
cHL
cell
lines
.
Diseases
Validation
Diseases presenting
"increased phosphorylation of igf1r"
symptom
hodgkin lymphoma, classical
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