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Expression of the active caspase-3 in children and adolescents with classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
aim
of
the
study
was
to
determine
whether
the
expression
of
active
caspase-
3
in
neoplastic
Hodgkin
and
Reed
-
Sternberg
(
H
/
RS
)
cells
correlates
with
the
treatment
response
and
provides
prognostic
information
on
treatment
outcome
.
In
this
retrospective
study
,
we
included
56
patients
with
classical
Hodgkin
lymphoma
treated
at
the
Department
of
Paediatric
Haematology
and
Oncology
between
January
2000
and
June
2005
.
Active
caspase-
3
was
detected
by
immunohistochemistry
in
primary
biopsy
specimens
.
Seventeen
patients
(
29
.
3
%
)
were
evaluated
as
caspase-
3
positive
and
remained
alive
in
the
first
complete
remission
.
This
stood
in
contrast
to
patients
with
less
than
5
%
caspase-
3
positive
cells
,
five
of
whom
experienced
relapse
and
three
patients
died
.
Adequate
treatment
response
was
achieved
in
11
patients
(
19
.
6
%
)
.
Comparison
of
event-free
survival
with
regard
to
the
percentage
of
caspase-
3
positive
tumour
cells
showed
a
tendency
for
a
better
clinical
outcome
in
patients
with
5
%
or
more
active
caspase-
3
positive
cells
.
Keywords
:
classical
Hodgkin
lymphoma
-
apoptosis
-
active
caspase-
3
-
therapy
response
-
clinical
outcome
.
Diseases
Validation
Diseases presenting
"positive cells"
symptom
canavan disease
carcinoma of the gallbladder
coats disease
congenital diaphragmatic hernia
dedifferentiated liposarcoma
epidermolysis bullosa simplex
erythropoietic protoporphyria
esophageal adenocarcinoma
hodgkin lymphoma, classical
severe combined immunodeficiency
werner syndrome
x-linked adrenoleukodystrophy
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