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Expression of the active caspase-3 in children and adolescents with classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
aim
of
the
study
was
to
determine
whether
the
expression
of
active
caspase-
3
in
neoplastic
Hodgkin
and
Reed
-
Sternberg
(
H
/
RS
)
cells
correlates
with
the
treatment
response
and
provides
prognostic
information
on
treatment
outcome
.
In
this
retrospective
study
,
we
included
56
patients
with
classical
Hodgkin
lymphoma
treated
at
the
Department
of
Paediatric
Haematology
and
Oncology
between
January
2000
and
June
2005
.
Active
caspase-
3
was
detected
by
immunohistochemistry
in
primary
biopsy
specimens
.
Seventeen
patients
(
29
.
3
%
)
were
evaluated
as
caspase-
3
positive
and
remained
alive
in
the
first
complete
remission
.
This
stood
in
contrast
to
patients
with
less
than
5
%
caspase-
3
positive
cells
,
five
of
whom
experienced
relapse
and
three
patients
died
.
Adequate
treatment
response
was
achieved
in
11
patients
(
19
.
6
%
)
.
Comparison
of
event-free
survival
with
regard
to
the
percentage
of
caspase-
3
positive
tumour
cells
showed
a
tendency
for
a
better
clinical
outcome
in
patients
with
5
%
or
more
active
caspase-
3
positive
cells
.
Keywords
:
classical
Hodgkin
lymphoma
-
apoptosis
-
active
caspase-
3
-
therapy
response
-
clinical
outcome
.
