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Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
[hodgkin lymphoma, classical]
Nodular
lymphocyte
predominant
Hodgkin
lymphoma
(
NLPHL
)
is
an
uncommon
variant
of
classical
Hodgkin
lymphoma
.
It
is
characterized
histologically
by
presence
of
lymphohistiocytic
cells
which
have
B-
cell
phenotype
,
are
positive
for
CD
19
,
CD
2
0
,
CD
4
5
,
CD
7
9
a
,
BOB
.
1
,
Oct
.
2
,
and
negative
for
CD
15
and
CD
30
.
Patients
often
present
with
early
stage
of
disease
and
do
not
have
classical
B
symptoms
.
The
clinical
behavior
appears
to
mimic
that
of
an
indolent
non-
Hodgkin
lymphoma
more
than
that
of
classical
Hodgkin
disease
.
The
purpose
of
the
present
report
is
to
define
the
biology
of
NLPHL
,
review
its
clinical
presentation
,
and
summarize
the
available
clinical
data
regarding
treatment
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated