Rare Diseases Symptoms Automatic Extraction

Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.

[hodgkin lymphoma, classical]

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.

Diseases presenting "early stage" symptom

  • adrenomyeloneuropathy
  • allergic bronchopulmonary aspergillosis
  • aromatase deficiency
  • cadasil
  • carcinoma of the gallbladder
  • child syndrome
  • cholangiocarcinoma
  • congenital adrenal hyperplasia
  • esophageal adenocarcinoma
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • familial hypocalciuric hypercalcemia
  • familial mediterranean fever
  • gm1 gangliosidosis
  • harlequin ichthyosis
  • hereditary cerebral hemorrhage with amyloidosis
  • hodgkin lymphoma, classical
  • kindler syndrome
  • lymphangioleiomyomatosis
  • neonatal adrenoleukodystrophy
  • pyomyositis
  • scrub typhus
  • sneddon syndrome
  • typhoid
  • von hippel-lindau disease
  • zellweger syndrome

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