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Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
[hodgkin lymphoma, classical]
Nodular
lymphocyte
predominant
Hodgkin
lymphoma
(
NLPHL
)
is
an
uncommon
variant
of
classical
Hodgkin
lymphoma
.
It
is
characterized
histologically
by
presence
of
lymphohistiocytic
cells
which
have
B-
cell
phenotype
,
are
positive
for
CD
19
,
CD
2
0
,
CD
4
5
,
CD
7
9
a
,
BOB
.
1
,
Oct
.
2
,
and
negative
for
CD
15
and
CD
30
.
Patients
often
present
with
early
stage
of
disease
and
do
not
have
classical
B
symptoms
.
The
clinical
behavior
appears
to
mimic
that
of
an
indolent
non-
Hodgkin
lymphoma
more
than
that
of
classical
Hodgkin
disease
.
The
purpose
of
the
present
report
is
to
define
the
biology
of
NLPHL
,
review
its
clinical
presentation
,
and
summarize
the
available
clinical
data
regarding
treatment
.
