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Livin, a novel marker in lymphoma type distinction.
[hodgkin lymphoma, classical]
Despite
advances
in
immunohistochemical
and
molecular
diagnostics
,
there
are
persistent
difficulties
in
differentiating
between
several
subtypes
of
non-
Hodgkin
lymphoma
(
NHL
)
and
classic
Hodgkin
lymphoma
(
CHL
)
.
Considering
high
level
of
livin
expression
in
hematologic
malignancies
,
we
aimed
to
examine
the
utility
of
livin
expression
ratio
,
as
an
ancillary
biomarker
,
in
distinguishing
CHL
from
NHL
in
ambiguous
cases
.
We
evaluated
livin
expression
in
38
CHL
,
23
NHL
,
and
39
nonneoplastic
lymph
nodes
in
paraffin-embedded
blocks
.
Tissue
microarray-based
semiquantitative
immunoflourecent
staining
was
applied
for
protein
expression
.
Criterion
standard
of
diagnosis
was
based
on
selection
of
only
definite
cases
and
not
the
cases
suspected
by
hemathopathologists
.
A
significant
difference
was
found
in
the
livin
/
GAPDH
mean
ratio
(
M
.
R
)
of
expression
between
NHL
and
CHL
cases
.
A
receiver
operating
characteristic
curve
analysis
confirmed
0
.
6370
to
be
the
best
diagnostic
cut-off
value
for
the
livin
/
GAPDH
expression
M
.
R
in
diffuse
large
B-
cell
lymphoma
(
DLBCL
)
(
area
under
the
curve
=
0
.
944
)
;
it
yielded
92
%
sensitivity
,
94
%
specificity
,
likelihood
ratios
positive
17
.
5
,
and
likelihood
ratios
negative
0
.
07
for
diagnosing
DLBCL
from
CHL
.
Mean
ratio
of
livin
/
Glyceraldehyde
3
-
phosphate
dehydrogenase
(
GAPDH
)
expression
seems
to
be
a
valuable
index
in
differentiating
DLBCL
from
CHL
.
We
suggested
an
optimal
cut-off
point
for
livin
/
GAPDH
expression
M
.
R
with
a
high
sensitivity
and
specificity
.
Thus
,
in
diagnostically
difficult
cases
of
DLBCL
and
CHL
,
focus
on
livin
as
marker
may
provide
useful
corroborative
information
.
Diseases
Validation
Diseases presenting
"high level"
symptom
22q11.2 deletion syndrome
aniridia
cadasil
carcinoma of the gallbladder
cohen syndrome
congenital toxoplasmosis
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentinogenesis imperfecta
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
hodgkin lymphoma, classical
inclusion body myositis
liposarcoma
lymphangioleiomyomatosis
omenn syndrome
oral submucous fibrosis
pyomyositis
scrub typhus
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
x-linked adrenoleukodystrophy
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