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Livin, a novel marker in lymphoma type distinction.
[hodgkin lymphoma, classical]
Despite
advances
in
immunohistochemical
and
molecular
diagnostics
,
there
are
persistent
difficulties
in
differentiating
between
several
subtypes
of
non-
Hodgkin
lymphoma
(
NHL
)
and
classic
Hodgkin
lymphoma
(
CHL
)
.
Considering
high
level
of
livin
expression
in
hematologic
malignancies
,
we
aimed
to
examine
the
utility
of
livin
expression
ratio
,
as
an
ancillary
biomarker
,
in
distinguishing
CHL
from
NHL
in
ambiguous
cases
.
We
evaluated
livin
expression
in
38
CHL
,
23
NHL
,
and
39
nonneoplastic
lymph
nodes
in
paraffin-embedded
blocks
.
Tissue
microarray-based
semiquantitative
immunoflourecent
staining
was
applied
for
protein
expression
.
Criterion
standard
of
diagnosis
was
based
on
selection
of
only
definite
cases
and
not
the
cases
suspected
by
hemathopathologists
.
A
significant
difference
was
found
in
the
livin
/
GAPDH
mean
ratio
(
M
.
R
)
of
expression
between
NHL
and
CHL
cases
.
A
receiver
operating
characteristic
curve
analysis
confirmed
0
.
6370
to
be
the
best
diagnostic
cut-off
value
for
the
livin
/
GAPDH
expression
M
.
R
in
diffuse
large
B-
cell
lymphoma
(
DLBCL
)
(
area
under
the
curve
=
0
.
944
)
;
it
yielded
92
%
sensitivity
,
94
%
specificity
,
likelihood
ratios
positive
17
.
5
,
and
likelihood
ratios
negative
0
.
07
for
diagnosing
DLBCL
from
CHL
.
Mean
ratio
of
livin
/
Glyceraldehyde
3
-
phosphate
dehydrogenase
(
GAPDH
)
expression
seems
to
be
a
valuable
index
in
differentiating
DLBCL
from
CHL
.
We
suggested
an
optimal
cut-off
point
for
livin
/
GAPDH
expression
M
.
R
with
a
high
sensitivity
and
specificity
.
Thus
,
in
diagnostically
difficult
cases
of
DLBCL
and
CHL
,
focus
on
livin
as
marker
may
provide
useful
corroborative
information
.
Diseases
Validation
Diseases presenting
"useful corroborative information"
symptom
hodgkin lymphoma, classical
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