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A random Abstract
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The role of the microenvironment in human immunodeficiency virus-associated classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
To
characterize
the
microenvironment
of
classical
Hodgkin
lymphoma
(
cHL
)
in
people
living
with
human
immunodeficiency
virus
(
PLWH
)
.
The
objective
was
to
identify
and
then
quantify
the
immune
cells
present
in
the
microenvironment
.
Ten
samples
of
cHL
from
PLWH
were
compared
with
10
samples
of
cHL
from
the
general
population
using
tissue
microarray
technology
and
immunohistochemistry
.
Sections
were
immunostained
with
antibodies
for
CD
30
,
CD
3
,
CD
4
,
CD
8
,
CD
2
0
,
CD
6
8
R
,
CD
5
6
,
CD
5
7
,
CD
123
,
FoxP
3
and
granzyme
B
.
A
statistically
significant
reduction
of
CD
4
(
+
)
T
cells
,
CD
5
6
(
+
)
cells
,
CD
5
7
(
+
)
cells
,
CD
123
(
+
)
cells
and
B
cells
and
an
increase
in
numbers
in
FoxP
3
(
+
)
CD
8
(
+
)
cells
was
observed
in
cHL
diagnosed
in
PLWH
.
No
significant
differences
were
seen
in
the
number
of
CD
8
(
+
)
T
cells
,
CD
4
(
+
)
FoxP
3
(
+
)
T
cells
and
macrophages
.
There
are
considerable
differences
in
the
microenvironment
of
cHL
occurring
with
and
without
HIV
.
Diseases
Validation
Diseases presenting
"immunodeficiency"
symptom
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
cushing syndrome
dracunculiasis
hirschsprung disease
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kabuki syndrome
legionellosis
malignant atrophic papulosis
oculocutaneous albinism
omenn syndrome
papillon-lefèvre syndrome
primary effusion lymphoma
primary hyperoxaluria type 1
pyomyositis
severe combined immunodeficiency
sneddon syndrome
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
