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The role of the microenvironment in human immunodeficiency virus-associated classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
To
characterize
the
microenvironment
of
classical
Hodgkin
lymphoma
(
cHL
)
in
people
living
with
human
immunodeficiency
virus
(
PLWH
)
.
The
objective
was
to
identify
and
then
quantify
the
immune
cells
present
in
the
microenvironment
.
Ten
samples
of
cHL
from
PLWH
were
compared
with
10
samples
of
cHL
from
the
general
population
using
tissue
microarray
technology
and
immunohistochemistry
.
Sections
were
immunostained
with
antibodies
for
CD
30
,
CD
3
,
CD
4
,
CD
8
,
CD
2
0
,
CD
6
8
R
,
CD
5
6
,
CD
5
7
,
CD
123
,
FoxP
3
and
granzyme
B
.
A
statistically
significant
reduction
of
CD
4
(
+
)
T
cells
,
CD
5
6
(
+
)
cells
,
CD
5
7
(
+
)
cells
,
CD
123
(
+
)
cells
and
B
cells
and
an
increase
in
numbers
in
FoxP
3
(
+
)
CD
8
(
+
)
cells
was
observed
in
cHL
diagnosed
in
PLWH
.
No
significant
differences
were
seen
in
the
number
of
CD
8
(
+
)
T
cells
,
CD
4
(
+
)
FoxP
3
(
+
)
T
cells
and
macrophages
.
There
are
considerable
differences
in
the
microenvironment
of
cHL
occurring
with
and
without
HIV
.
Diseases
Validation
Diseases presenting
"statistically significant reduction"
symptom
hirschsprung disease
hodgkin lymphoma, classical
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