Rare Diseases Symptoms Automatic Extraction

Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma.

[hodgkin lymphoma, classical]

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare Hodgkin lymphoma distinguished from classical Hodgkin lymphoma (cHL) by the nature of the neoplastic cells which express B-cell markers. We wanted to determine the diagnostic performance of FDG PET/CT in initial assessment and its therapeutic impact on staging.We retrospectively studied a population of 35 patients with NLPHL (8 previously treated for NLHPL, 27 untreated). All patients underwent an initial staging by pretherapeutic FDG PET/CT. The impact on initial stage or relapse stage was assessed by an independent physician.In a per-patient analysis, the sensitivity of the pretherapeutic FDG PET/CT was 100%. In a per-site analysis, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pretherapeutic FDG PET/CT were 100%, 99%, 97%, 100% and 99%, respectively. Pretherapeutic FDG PET/CT led to a change in the initial stage/relapse stage in 12 of the 35 patients (34%). In contrast to previous results established without FDG PET/CT, 20% of patient had osteomedullary lesions.Pretherapeutic FDG PET/CT has excellent performance for initial staging or relapse staging of NLPHL.

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  • cholangiocarcinoma
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  • congenital diaphragmatic hernia
  • congenital toxoplasmosis
  • cushing syndrome
  • esophageal adenocarcinoma
  • esophageal carcinoma
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  • heparin-induced thrombocytopenia
  • hodgkin lymphoma, classical
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  • thoracic outlet syndrome
  • typhoid

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