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Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant.
[hodgkin lymphoma, classical]
Primary
cutaneous
follicle
center
lymphoma
(
PCFCL
)
is
the
most
frequent
cutaneous
B-
cell
lymphoma
.
A
62
-
year
-old
man
presented
with
a
solitary
indolent
subcutaneous
nodule
for
3
years
duration
,
without
other
abnormalities
.
Histological
examination
showed
lymphoproliferation
with
a
nodular
growth
pattern
characterized
by
fibrous
collagen
bands
surrounding
nodules
.
The
nodules
were
composed
of
medium-sized
centrocytes
admixed
with
many
large
multilobulated
and
lacunar
cells
without
eosinophils
or
granulomatous
aspect
.
Hodgkin-like
cells
were
CD
30
+
,
CD
15
+
,
PAX
5
+
,
OCT
2
+
,
BOB
1
+
,
MUM
1
+
,
Ki
67
+
,
Bcl
6
+
and
focally
CD
2
0
+
and
EMA-
,
CD
7
9
a-
,
Bcl
2
-
and
CD
10
-
.
The
medium-sized
cells
were
CD
2
0
+
,
CD
7
9
a
+
,
Bcl
2
+
,
Bcl
6
+
and
CD
10
+
,
enmeshed
in
a
network
of
CD
2
1
-
positive
follicular
dendritic
cells
.
Epstein-
Barr
virus
detection
was
negative
.
Interphase
fluorescence
in
situ
hybridization
showed
the
absence
of
BCL
2
or
BCL
6
rearrangement
.
In
such
a
case
,
the
presence
of
Hodgkin-like
cells
intermixed
with
the
tumor
population
may
result
in
a
pitfall
diagnosis
of
classical
Hodgkin
lymphoma
(
CHL
)
.
Differential
diagnoses
to
be
ruled
out
are
secondary
or
primary
skin
localization
of
rather
CHL
,
or
systemic
follicular
lymphoma
.
Several
clinical
,
radiological
,
histological
,
immunohistochemical
and
molecular
arguments
indicated
the
diagnosis
of
PCFCL
.
To
our
knowledge
,
this
is
the
first
report
of
PCFCL
with
Hodgkin-like
cells
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated