Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant.

[hodgkin lymphoma, classical]

Primary cutaneous follicle center lymphoma (PCFCL ) is the most frequent cutaneous B-cell lymphoma . A 62 -year -old man presented with a solitary indolent subcutaneous nodule for 3 years duration , without other abnormalities . Histological examination showed lymphoproliferation with a nodular growth pattern characterized by fibrous collagen bands surrounding nodules . The nodules were composed of medium-sized centrocytes admixed with many large multilobulated and lacunar cells without eosinophils or granulomatous aspect . Hodgkin-like cells were CD 30 +, CD 15 +, PAX 5 +, OCT 2 +, BOB 1 +, MUM 1 +, Ki 67 +, Bcl 6 + and focally CD 2 0 + and EMA-, CD 7 9 a-, Bcl 2 - and CD 10 -. The medium-sized cells were CD 2 0 +, CD 7 9 a +, Bcl 2 +, Bcl 6 + and CD 10 +, enmeshed in a network of CD 2 1 -positive follicular dendritic cells . Epstein-Barr virus detection was negative . Interphase fluorescence in situ hybridization showed the absence of BCL 2 or BCL 6 rearrangement . In such a case , the presence of Hodgkin-like cells intermixed with the tumor population may result in a pitfall diagnosis of classical Hodgkin lymphoma (CHL ). Differential diagnoses to be ruled out are secondary or primary skin localization of rather CHL , or systemic follicular lymphoma . Several clinical , radiological , histological , immunohistochemical and molecular arguments indicated the diagnosis of PCFCL . To our knowledge , this is the first report of PCFCL with Hodgkin-like cells .

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achondroplasia

alexander disease

aniridia

cadasil

canavan disease

child syndrome

cohen syndrome

congenital toxoplasmosis

cowden syndrome

cushing syndrome

cutaneous mastocytosis

cystinuria

dedifferentiated liposarcoma

dentinogenesis imperfecta

dracunculiasis

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

esophageal squamous cell carcinoma

fabry disease

familial mediterranean fever

focal myositis

harlequin ichthyosis

hirschsprung disease

hodgkin lymphoma, classical

holt-oram syndrome

homocystinuria without methylmalonic aciduria

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kindler syndrome

krabbe disease

lamellar ichthyosis

liposarcoma

lymphangioleiomyomatosis

monosomy 21

neonatal adrenoleukodystrophy

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oligodontia

omenn syndrome

pendred syndrome

pleomorphic liposarcoma

primary hyperoxaluria type 1

pyomyositis

pyruvate dehydrogenase deficiency

scrub typhus

severe combined immunodeficiency

sneddon syndrome

triple a syndrome

typhoid

waldenström macroglobulinemia

werner syndrome

wiskott-aldrich syndrome

x-linked adrenoleukodystrophy

zellweger syndrome

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