Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets.
[hodgkin lymphoma, classical]
Despite
the
immunologic
functions
of
T
-
cell
receptor
signaling
molecules
being
extensively
investigated
,
their
potential
as
immunohistochemical
markers
has
been
poorly
explored
.
With
this
background
,
we
evaluated
the
expression
of
5
intracellular
proteins-
GADS
,
DOK
2
,
SKAP
55
,
ITK
,
and
PKC
α-involved
in
T
-
cell
receptor
signaling
in
normal
and
neoplastic
hematologic
tissue
samples
,
using
antibodies
raised
against
fixation-resistant
epitopes
of
the
5
molecules
.
All
5
antibodies
were
associated
with
normal
T
-
cell
differentiation
.
GADS
,
DOK
2
,
SKAP
55
,
and
ITK
turned
out
to
be
T
-
cell
lineage-
specific
markers
in
the
setting
of
lymphoid
and
myeloid
precursor
neoplasms
but
showed
differential
expression
in
peripheral
T-
cell
lymphoma
(
PTCL
)
subtypes
,
being
detected
in
PTCL
/
not
otherwise
specified
(
NOS
)
and
angioimmunoblastic
T-
cell
lymphoma
but
negative
in
anaplastic
large
cell
lymphoma
(
ALCL
)
.
Peripheral
B-
cell
lymphomas
were
consistently
negative
for
ITK
,
with
occasional
cases
showing
expression
of
DOK
2
and
SKAP
55
,
and
a
proportion
(
47
%
)
of
hairy
cell
leukemias
were
GADS
.
Notably
,
PKC
α
highlighted
a
defective
antigen
in
both
PTCL
/
NOS
(
6
%
)
and
angioimmunoblastic
T-
cell
lymphoma
(
10
%
)
,
mostly
negative
in
ALCL
,
and
was
aberrantly
expressed
in
classical
Hodgkin
lymphoma
(
65
%
)
,
Burkitt
lymphoma
(
48
%
)
,
and
plasma
cell
myeloma
(
48
%
)
.
In
conclusion
,
all
five
molecules
evaluated
play
a
role
in
T
-
cell
differentiation
in
normal
and
neoplastic
tissues
.
They
can
be
applied
confidently
to
routine
sections
contributing
primarily
to
assignment
of
T
-
lineage
differentiation
in
the
setting
of
hematopoietic
precursor
neoplasms
(
GADS
/
DOK
2
/
SKAP
55
/
ITK
)
and
for
the
differential
diagnosis
between
ALCL
and
PTCL
/
NOS
(
GADS
/
DOK
2
/
SKAP
55
/
ITK
)
or
classical
Hodgkin
lymphoma
(
PKC
α
)
.
Finally
,
association
with
specific
tumor
subtypes
may
have
therapeutic
potential
.
Diseases
Validation
Diseases presenting
"anaplastic large cell lymphoma"
symptom
hodgkin lymphoma, classical
systemic capillary leak syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom