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Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy.
[hodgkin lymphoma, classical]
The
levels
of
serum
beta
-
2
microglobulin
(
β
2
MG
)
are
determined
mainly
from
lymphoid
tissue
.
To
examine
its
prognostic
value
in
Hodgkin
lymphoma
(
HL
)
,
we
conducted
a
retrospective
analysis
.
We
analyzed
67
patients
with
HL
diagnosed
and
treated
at
seven
institutes
of
the
Yokohama
City
University
Hematology
Group
between
1998
and
2011
.
The
patients
included
40
males
and
27
females
with
a
median
age
of
41
years
(
range
16
-
81
years
)
.
The
HL
subtypes
were
nodular
sclerosis
classical
HL
in
37
patients
,
mixed
cellular
classical
HL
in
23
,
lymphocyte-rich
classical
HL
in
6
,
and
nodular
lymphocyte-predominant
HL
in
1
.
The
4
-
year
overall
survival
(
OS
)
rate
of
all
67
patients
was
89
%
.
Patients
with
β
2
MG
levels
≥
2
.
5
mg
/
L
(
n
=
18
)
showed
inferior
progression-free
survival
(
PFS
;
4
-
year
PFS
rate
,
42
%
)
and
inferior
OS
(
4
-
year
OS
rate
,
60
%
)
compared
to
patients
who
had
β
2
MG
levels
<
2
.
5
mg
/
L
(
n
=
49
;
4
-
year
PFS
rate
,
87
%
;
4
-
year
OS
rate
,
98
%
;
P
<
0
.
001
)
.
In
multivariate
analysis
,
only
a
serum
β
2
MG
level
≥
2
.
5
mg
/
L
was
a
significant
adverse
prognostic
factor
in
regard
to
PFS
(
P
=
0
.
04
;
relative
risk
3
.
57
)
.
However
,
it
was
not
significant
prognostic
factor
for
OS
(
P
=
0
.
16
)
in
the
multivariate
analysis
.
The
serum
β
2
MG
level
at
diagnosis
is
a
useful
prognostic
marker
in
patients
with
HL
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated