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Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy.
[hodgkin lymphoma, classical]
The
levels
of
serum
beta
-
2
microglobulin
(
β
2
MG
)
are
determined
mainly
from
lymphoid
tissue
.
To
examine
its
prognostic
value
in
Hodgkin
lymphoma
(
HL
)
,
we
conducted
a
retrospective
analysis
.
We
analyzed
67
patients
with
HL
diagnosed
and
treated
at
seven
institutes
of
the
Yokohama
City
University
Hematology
Group
between
1998
and
2011
.
The
patients
included
40
males
and
27
females
with
a
median
age
of
41
years
(
range
16
-
81
years
)
.
The
HL
subtypes
were
nodular
sclerosis
classical
HL
in
37
patients
,
mixed
cellular
classical
HL
in
23
,
lymphocyte-rich
classical
HL
in
6
,
and
nodular
lymphocyte-predominant
HL
in
1
.
The
4
-
year
overall
survival
(
OS
)
rate
of
all
67
patients
was
89
%
.
Patients
with
β
2
MG
levels
≥
2
.
5
mg
/
L
(
n
=
18
)
showed
inferior
progression-free
survival
(
PFS
;
4
-
year
PFS
rate
,
42
%
)
and
inferior
OS
(
4
-
year
OS
rate
,
60
%
)
compared
to
patients
who
had
β
2
MG
levels
<
2
.
5
mg
/
L
(
n
=
49
;
4
-
year
PFS
rate
,
87
%
;
4
-
year
OS
rate
,
98
%
;
P
<
0
.
001
)
.
In
multivariate
analysis
,
only
a
serum
β
2
MG
level
≥
2
.
5
mg
/
L
was
a
significant
adverse
prognostic
factor
in
regard
to
PFS
(
P
=
0
.
04
;
relative
risk
3
.
57
)
.
However
,
it
was
not
significant
prognostic
factor
for
OS
(
P
=
0
.
16
)
in
the
multivariate
analysis
.
The
serum
β
2
MG
level
at
diagnosis
is
a
useful
prognostic
marker
in
patients
with
HL
.
Diseases
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Diseases presenting
"useful prognostic marker in patients"
symptom
hodgkin lymphoma, classical
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