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Prognostic significance of immunophenotypes and a nodular pattern in primary mediastinal large B-cell lymphoma.
[hodgkin lymphoma, classical]
To
investigate
the
clinicopathological
and
prognostic
significance
of
a
nodular
pattern
and
immunophenotypes
in
primary
mediastinal
large
B-
cell
lymphoma
(
PMBL
)
,
histopathological
features
,
including
a
nodular
pattern
and
immunophenotypes
,
were
analyzed
in
58
Japanese
PMBL
patients
.
The
patients
were
23
men
and
35
women
with
a
median
age
of
31
years
.
The
4
-
year
progression
free
survival
(
PFS
)
rate
was
78
%
,
and
the
4
-
year
overall
survival
(
OS
)
rate
was
89
%
.
Among
the
histopathological
and
immunohistochemical
features
,
Bcl
6
(
+
)
(
P
=
0
.
013
)
,
MUM
1
(
+
)
(
P
=
0
.
091
)
,
and
pale
cytoplasm
(
P
=
0
.
064
)
were
favorable
prognostic
indicators
of
PFS
,
and
Bcl
6
(
+
)
(
P
=
0
.
051
)
and
MUM
1
(
+
)
(
P
=
0
.
07
)
were
favorable
prognostic
indicators
of
OS
.
Patients
with
Bcl
2
negativity
(
n
=
11
)
had
4
-
year
PFS
and
OS
rates
of
100
%
.
Histologically
,
a
nodular
pattern
,
resembling
nodular
sclerosis
classical
Hodgkin
lymphoma
(
CHL
)
,
was
observed
in
22
patients
(
38
%
)
.
However
,
this
was
not
a
significant
prognostic
indicator
.
In
conclusion
,
Bcl
6
(
+
)
,
MUM
1
(
+
)
,
Bcl
2
(
-
)
,
and
pale
cytoplasm
are
candidate
favorable
prognostic
indicators
for
PMBL
and
should
be
further
examined
in
larger
studies
.
We
suggest
that
PMBL
with
a
nodular
pattern
may
belong
to
the
same
histological
spectrum
as
nodular
sclerosis
CHL
.
Diseases
Validation
Diseases presenting
"resembling nodular sclerosis classical hodgkin lymphoma"
symptom
hodgkin lymphoma, classical
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