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Clinical characteristics of 26 patients with primary extranodal Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Most
Hodgkin
lymphoma
(
HL
)
patients
present
with
disease
in
nodal
regions
.
However
,
in
a
small
subset
,
disease
develops
extranodal
sites
primarily
,
such
as
lung
and
liver
.
This
study
aims
to
identify
the
characteristics
and
outcomes
of
patients
with
primary
extranodal
HL
.
A
retrospective
analysis
of
patients
with
HL
from
1998
to
2012
was
enrolled
.
We
selected
26
HL
patients
with
primary
extranodal
involvement
from
251
previously
untreated
HL
patients
.
All
data
analyses
were
performed
with
SPSS
software
version
17
.
0
and
GraphPad
Prism
5
.
We
identified
26
patients
with
primary
extranodal
HL
.
Results
in
the
series
of
young
patients
,
male
predominated
.
Pathologically
,
the
major
pathologic
types
were
nodular
sclerosis
classical
HL
(
NSCHL
,
46
.
2
%
)
and
mixed
cellularity
classical
HL
(
MCCHL
,
38
.
5
%
)
.
Thirteen
patients
had
early
stage
(
I
or
II
stage
)
.
The
most
commonly
primarily
extranodal
sites
were
the
lung
and
the
stomach
and
intestine
,
followed
by
the
liver
and
bones
.
Fifteen
of
26
received
chemotherapy
alone
and
11
received
combination
therapy
.
Finally
,
primary
extranodal
HLs
in
our
study
have
a
favorable
survival
.
Furthermore
,
there
was
no
significant
association
between
the
international
prognostic
score
(
IPS
)
and
survival
in
patients
with
extranodal
HL
.
Our
retrospective
data
in
part
reflect
clinical
characteristics
of
primary
extranodal
HL
in
China
,
and
form
the
basis
for
further
concerning
researches
.
Diseases
Validation
Diseases presenting
"early stage"
symptom
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
aromatase deficiency
cadasil
carcinoma of the gallbladder
child syndrome
cholangiocarcinoma
congenital adrenal hyperplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
hereditary cerebral hemorrhage with amyloidosis
hodgkin lymphoma, classical
kindler syndrome
lymphangioleiomyomatosis
neonatal adrenoleukodystrophy
pyomyositis
scrub typhus
sneddon syndrome
typhoid
von hippel-lindau disease
zellweger syndrome
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