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CD68 staining correlates with the size of residual mass but not with survival in classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
prognostic
role
of
CD
68
tumor
-associated
macrophages
in
classic
Hodgkin
lymphoma
(
cHL
)
remains
controversial
.
We
stained
diagnostic
biopsies
and
scored
for
CD
68
using
the
PGM
1
antibody
among
98
consecutive
patients
with
cHL
from
our
center
followed
over
a
median
of
45
months
for
progression-free
survival
(
PFS
)
.
Among
79
patients
we
assessed
interim
and
post-treatment
positron
emission
tomography-computed
tomography
(
PET-
CT
)
.
Residual
mass
(
RM
)
size
was
based
on
the
greatest
diameter
of
the
largest
mass
seen
in
post-treatment
imaging
,
and
percent
reduction
was
calculated
by
comparing
RM
size
with
its
greatest
pretreatment
diameter
.
We
found
a
significant
association
between
CD
68
positivity
and
absolute
size
of
initial
disease
mass
(
p
=
0
.
014
)
and
residual
mass
at
the
end
of
therapy
(
p
=
0
.
006
)
but
no
association
was
observed
with
interim
PET-
CT
results
or
PFS
.
Our
findings
suggest
that
macrophages
may
influence
tumor
size
by
altering
the
microenvironment
.
This
study
does
not
support
a
prognostic
role
of
CD
68
positivity
in
predicting
survival
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated