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CD68 staining correlates with the size of residual mass but not with survival in classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
prognostic
role
of
CD
68
tumor
-associated
macrophages
in
classic
Hodgkin
lymphoma
(
cHL
)
remains
controversial
.
We
stained
diagnostic
biopsies
and
scored
for
CD
68
using
the
PGM
1
antibody
among
98
consecutive
patients
with
cHL
from
our
center
followed
over
a
median
of
45
months
for
progression-free
survival
(
PFS
)
.
Among
79
patients
we
assessed
interim
and
post-treatment
positron
emission
tomography-computed
tomography
(
PET-
CT
)
.
Residual
mass
(
RM
)
size
was
based
on
the
greatest
diameter
of
the
largest
mass
seen
in
post-treatment
imaging
,
and
percent
reduction
was
calculated
by
comparing
RM
size
with
its
greatest
pretreatment
diameter
.
We
found
a
significant
association
between
CD
68
positivity
and
absolute
size
of
initial
disease
mass
(
p
=
0
.
014
)
and
residual
mass
at
the
end
of
therapy
(
p
=
0
.
006
)
but
no
association
was
observed
with
interim
PET-
CT
results
or
PFS
.
Our
findings
suggest
that
macrophages
may
influence
tumor
size
by
altering
the
microenvironment
.
This
study
does
not
support
a
prognostic
role
of
CD
68
positivity
in
predicting
survival
.