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Genetic Associations in Classical Hodgkin Lymphoma: A Systematic Review and Insights into Susceptibility Mechanisms.
[hodgkin lymphoma, classical]
Both
targeted
and
genome-
wide
studies
have
revealed
genetic
associations
for
susceptibility
,
prognosis
,
and
treatment-induced
secondary
malignancies
and
toxicities
in
classical
Hodgkin
lymphoma
(
cHL
)
.
This
review
gives
a
systematic
and
comprehensive
overview
of
significant
associations
and
places
them
into
a
biologic
context
.
The
strongest
susceptibility
polymorphisms
have
been
found
for
the
human
leukocyte
antigen
(
HLA
)
genes
.
These
associations
are
specific
for
cHL
overall
or
for
subgroups
based
on
tumor
cell
Epstein-
Barr
virus
(
EBV
)
status
.
These
findings
strongly
suggest
that
EBV-
specific
immune
responses
influence
cHL
susceptibility
in
EBV
(
+
)
cHL
and
that
immune
responses
targeting
other
tumor
-associated
antigens
are
important
in
EBV
(
-
)
cHL
.
Accordingly
,
most
of
the
numerous
other
susceptibility
loci
map
to
genes
that
affect
functionality
of
the
immune
system
,
underscoring
the
crucial
role
of
the
immune
system
in
cHL
development
.
The
number
of
association
studies
on
cHL
prognosis
is
limited
with
one
consistent
association
for
the
drug-metabolizing
UGT
1
A
1
gene
.
PRDM
1
is
associated
with
radiation-induced
secondary
malignancies
and
a
small
number
of
genes
are
associated
with
treatment-related
toxicities
.
In
conclusion
,
most
loci
showing
genetic
associations
in
cHL
harbor
genes
with
a
potential
functional
relevance
for
cHL
susceptibility
.
Cancer
Epidemiol
Biomarkers
Prev
;
23
(
12
)
;
1
-
11
.
©
2014
AACR
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated