Rare Diseases Symptoms Automatic Extraction

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

[hodgkin lymphoma, classical]

The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-κB, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain low in cHL. FOXO1, playing a critical role in normal B-cell development, acts as a tumor suppressor in cHL, but has never been associated with induction of PC differentiation. Here we show that FOXO1 directly upregulates the full-length isoform PRDM1α in cHL cell lines. We also observed a positive correlation between FOXO1 and PRDM1 expression levels in primary Hodgkin-Reed-Sternberg cells. Further, we show that PRDM1α acts as a tumor suppressor in cHL at least partially by blocking MYC. Here we provide a link between FOXO1 repression and PRDM1α downregulation in cHL and identify PRDM1α as a tumor suppressor in cHL. The data support a potential role for FOXO transcription factors in normal PC differentiation.

Diseases presenting "positive correlation" symptom

  • 22q11.2 deletion syndrome
  • acute rheumatic fever
  • adrenal incidentaloma
  • aromatase deficiency
  • congenital adrenal hyperplasia
  • congenital diaphragmatic hernia
  • cutaneous mastocytosis
  • dedifferentiated liposarcoma
  • familial mediterranean fever
  • hodgkin lymphoma, classical
  • inclusion body myositis
  • kallmann syndrome
  • legionellosis
  • oral submucous fibrosis
  • trochlear dysplasia
  • well-differentiated liposarcoma

You can validate or delete this automatically detected symptom