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Relationship of intratumoural protein expression patterns to age and Epstein-Barr virus status in classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
In
Western
countries
,
the
age
distribution
of
Hodgkin
lymphoma
(
HL
)
follows
a
characteristic
bimodal
curve
showing
an
early
and
a
late
peak
at
approximately
35
and
70
Â
yr
,
respectively
.
Furthermore
,
the
presence
of
latent
Epstein-
Barr
virus
(
EBV
)
genome
in
the
Hodgkin
Reed
-
Sternberg
cells
,
the
tumour
cell
population
of
classical
HL
(
cHL
)
,
has
been
found
to
have
adverse
prognostic
impact
in
elderly
,
but
not
in
younger
cHL
patients
.
We
have
characterised
the
protein
expression
in
tumour
tissue
samples
from
younger
(
≤
55
Â
yr
)
and
elderly
(
>
55
Â
yr
)
cHL
patients
and
correlated
the
findings
with
EBV
status
.
Differentially
expressed
proteins
according
to
patients
'
age
as
well
as
tumoural
EBV
status
belonged
to
different
biological
functional
domains
,
such
as
apoptosis
,
cytoskeletal
organisation
,
response
to
oxygen
levels
and
regulation
of
catabolic
/
metabolic
processes
.
The
differential
expression
of
selected
proteins
,
cytosolic
aminopeptidase
,
heterogeneous
nuclear
ribonucleoprotein
K
,
serotransferrin
and
alpha-
1
-
antitrypsin
was
further
validated
by
Western
blot
analysis
.
Discovery
-based
proteomics
characterising
biological
features
distinctive
for
subsets
of
cHL
patients
may
be
useful
for
the
identification
of
novel
biomarkers
with
potential
therapeutic
relevance
.
An
evaluation
of
the
prognostic
impact
of
protein
expression
pattern
in
general
and
individually
expressed
proteins
in
particular
is
warranted
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated
