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BOB.1-positive Classical Hodgkin's Lymphoma Carries Hypermethylation of Its Promoter as Epigenetic Marker of Gene-silencing Memory.
[hodgkin lymphoma, classical]
Analysis
of
archival
formalin-fixed
,
paraffin-embedded
(
FFPE
)
pathological
specimens
of
three
case
of
Epstein-
Barr
virus
(
EBV
)
-
positive
diffuse
large
B-
cell
lymphoma
(
DLBCL
)
and
three
cases
of
classical
Hodgkin
lymphoma
(
CHL
)
revealed
that
hypermethylation
of
the
BOB
.
1
gene
promoter
was
exclusively
observed
in
CHL
.
A
discrepancy
was
observed
,
however
,
between
the
methylation
status
of
the
BOB
.
1
gene
promoter
and
its
expression
in
the
EBV-
positive
mixed
cellular
CHL
(
MCCHL
)
.
Since
MCCHL
lacks
the
typical
B-
cell
phenotype
even
in
the
presence
of
abundant
BOB
.
1
transcription
factors
,
functional
activity
of
BOB
.
1
may
be
lost
or
reduced
by
a
mechanism
other
than
epigenetic
gene
silencing
.
When
some
tumor
-suppressor
gene
products
have
lost
their
biological
function
,
impact
or
significance
of
derepression
of
such
genes
may
be
little
.
Therefore
,
when
interpreting
immunohistochemical
results
for
diagnostic
or
research
purposes
,
it
must
be
borne
in
mind
that
apparent
positive
immunostaining
can
merely
be
the
result
of
chromatin
remodeling
and
that
such
transient
expression
often
has
little
functional
significance
.
Any
apparent
positive
immunohistochemical
result
needs
to
be
interpreted
carefully
with
the
help
of
the
hypermethylation
status
as
a
molecular
marker
of
gene
silencing
memory
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated
