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A random Abstract
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Germ-Line Transmitted, Chromosomally Integrated HHV-6 and Classical Hodgkin Lymphoma.
[hodgkin lymphoma, classical]
A
unique
feature
of
both
human
herpesvirus
6
A
and
B
(
HHV-
6
A
and
B
)
among
human
herpesviruses
is
their
ability
to
integrate
into
chromosomal
telomeres
.
In
some
individuals
integrated
viral
genomes
are
present
in
the
germ-line
and
result
in
the
vertical
transmission
of
HHV-
6
;
however
,
little
is
known
about
the
disease
associations
of
germ-line
transmitted
,
chromosomally
integrated
HHV-
6
(
ciHHV-
6
)
.
Recent
publications
suggest
that
HHV-
6
is
associated
with
classical
Hodgkin
lymphoma
(
cHL
)
.
Here
we
examine
the
prevalence
of
ciHHV-
6
in
936
cases
of
cHL
and
563
controls
by
screening
with
a
duplex
TaqMan
assay
and
confirming
with
droplet
digital
PCR
.
ciHHV-
6
was
detected
in
10
/
563
(
1
.
8
%
)
controls
and
in
all
but
one
individual
the
virus
was
HHV-
6
B
.
Amongst
cases
16
/
936
(
1
.
7
%
)
harboured
ciHHV-
6
,
thus
demonstrating
no
association
between
ciHHV-
6
and
risk
of
cHL
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated
