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Germ-Line Transmitted, Chromosomally Integrated HHV-6 and Classical Hodgkin Lymphoma.
[hodgkin lymphoma, classical]
A
unique
feature
of
both
human
herpesvirus
6
A
and
B
(
HHV-
6
A
and
B
)
among
human
herpesviruses
is
their
ability
to
integrate
into
chromosomal
telomeres
.
In
some
individuals
integrated
viral
genomes
are
present
in
the
germ-line
and
result
in
the
vertical
transmission
of
HHV-
6
;
however
,
little
is
known
about
the
disease
associations
of
germ-line
transmitted
,
chromosomally
integrated
HHV-
6
(
ciHHV-
6
)
.
Recent
publications
suggest
that
HHV-
6
is
associated
with
classical
Hodgkin
lymphoma
(
cHL
)
.
Here
we
examine
the
prevalence
of
ciHHV-
6
in
936
cases
of
cHL
and
563
controls
by
screening
with
a
duplex
TaqMan
assay
and
confirming
with
droplet
digital
PCR
.
ciHHV-
6
was
detected
in
10
/
563
(
1
.
8
%
)
controls
and
in
all
but
one
individual
the
virus
was
HHV-
6
B
.
Amongst
cases
16
/
936
(
1
.
7
%
)
harboured
ciHHV-
6
,
thus
demonstrating
no
association
between
ciHHV-
6
and
risk
of
cHL
.
Diseases
Validation
Diseases presenting
"classical hodgkin lymphoma"
symptom
hodgkin lymphoma, classical
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