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Characterization of the intestinal microbiome of Hirschsprung's disease with and without enterocolitis.
[hirschsprung disease]
Hirschsprung
's
disease
(
HD
)
is
a
congenital
malformation
of
the
gastrointestinal
tract
characterized
by
the
absence
of
the
distal
enteric
nervous
system
.
Hirschsprung-associated
enterocolitis
(
HAEC
)
is
severe
life
threatening
complication
of
HD
.
The
disease
pathogenesis
is
still
unclear
,
but
evidences
suggest
that
the
intestinal
microbiota
may
play
important
role
in
the
development
of
HD
and
HAEC
.
Because
microbial
abundance
and
diversity
might
differ
in
HD
patients
with
enterocolitis
,
we
sought
to
generate
comparative
metagenomic
signatures
to
characterize
the
structure
of
the
microbiome
in
HD
patients
with
and
without
enterocolitis
.
Our
experimental
design
is
to
enroll
four
HD
patients
(
two
with
enterocolitis
and
two
without
enterocolitis
)
.
The
microbiome
was
characterized
by
16
S
rRNA
gene
,
and
the
data
obtained
will
be
used
to
taxonomically
classify
and
compare
community
structure
among
different
samples
.
We
found
that
the
structure
of
the
microbiome
within
HAEC
patients
are
differ
from
those
without
enterocolitis
.
This
study
helps
us
to
understand
microbial
contributions
to
the
etiology
of
Hirschsprung-associated
enterocolitis
.
Diseases
Validation
Diseases presenting
"malformation of the gastrointestinal tract"
symptom
hirschsprung disease
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