Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Botulinum toxin use in paediatric colorectal surgery.
[hirschsprung disease]
To
evaluate
outcomes
of
intrasphincteric
botulinum
toxin
injection
(
ISBTI
)
in
children
with
intractable
constipation
.
Retrospective
case-note
review
of
patients
≤
16
years
of
age
undergoing
ISBTI
between
January
2010
and
February
2014
.
Data
collected
included
patient
demographics
,
diagnosis
,
complications
,
follow-up
duration
and
functional
outcomes
.
Successful
outcome
was
defined
as
resolution
/
improvement
in
symptoms
and
failed
when
there
was
no
change
in
symptoms
.
Statistical
analyses
were
performed
using
PRISM
(
GraphPad
,
CA
,
USA
)
.
p
values
<
0
.
05
were
considered
as
significant
.
43
patients
[
male
29
,
median
age
5
years
9
months
(
range
13
months
-
13
years
5
months
)
]
underwent
86
ISBTIs
.
Underlying
diagnoses
were
idiopathic
constipation
(
67
%
)
,
Hirschsprung
disease
(
26
%
)
,
anorectal
malformation
(
5
%
)
,
gastrointestinal
dysmotility
(
2
%
)
.
72
%
(
31
/
43
)
reported
improvement
in
symptoms
after
the
first
ISBTI
.
39
%
of
patients
had
recurrence
of
symptoms
at
12
-
month
median
follow-up
.
10
patients
non-responsive
to
ISBTI
required
an
antegrade
continence
enema
or
stoma
.
There
was
no
correlation
between
age
(
p
=
0
.
3
)
,
gender
(
p
=
0
.
7
)
,
diagnosis
(
p
 
=
0
.
84
)
,
or
number
of
ISBTIs
(
p
=
0
.
17
)
with
successful
outcome
.
Successful
outcomes
occurred
in
72
%
patients
after
the
first
ISBTI
.
25
%
required
further
surgical
management
of
their
symptoms
.
Further
work
is
required
to
help
predict
which
patients
will
benefit
from
ISBTI
.
Diseases
Validation
Diseases presenting
"gastrointestinal dysmotility"
symptom
hirschsprung disease
megacystis-microcolon-intestinal hypoperistalsis syndrome
This symptom has already been validated
