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A random Abstract
Our Project
Our Team
[Subtle brain abnormalities in adrenomyeloneuropathy].
[adrenomyeloneuropathy]
To
describe
subtle
brain
abnormalities
detected
on
MRI
in
adult
patients
with
adrenomyeloneuropathy
(
AMN
)
.
Materials
and
methods
.
Retrospective
evaluation
of
data
acquired
prospectively
as
part
of
a
clinical
trial
(
Riluzole
)
in
66
adult
patients
with
AMN
without
obvious
brain
lesion
on
MR
.
All
patients
underwent
brain
MR
including
T
1
W
,
T
2
W
,
FLAIR
and
spectroscopy
.
After
a
review
had
been
validated
by
three
different
reviewers
,
review
of
MR
images
was
performed
by
consensus
using
a
semi-quantitative
scale
.
Preliminary
analysis
of
MR
images
confirmed
the
presence
of
signal
abnormalities
involving
the
corticospinal
tracts
in
36
patients
(
54
.
6
%
)
.
Additional
subtle
abnormalities
were
also
detected
:
white
matter
palor
,
mainly
parieto-
occipital
in
location
,
with
patchy
hyperintensity
in
36
patients
(
54
.
6
%
)
,
hyperintense
pontocerebellar
fibers
on
T
2
W
and
FLAIR
in
25
patients
(
41
.
7
%
)
.
The
presence
of
elevated
Cho
/
Cr
and
mI
/
Cr
ratios
,
described
in
the
literature
,
were
confirmed
.
This
retrospective
study
allows
the
description
of
an
AMN
pattern
on
MRI
in
patients
without
white
matter
or
callosal
abnormalities
.
