Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Cortical tissue of patients with hereditary cerebral hemorrhage with amyloidosis (Dutch) contains various extracellular matrix deposits.
[hereditary cerebral hemorrhage with amyloidosis]
Hereditary
cerebral
hemorrhage
with
amyloidosis
(
Dutch
)
(
HCHWA-D
)
and
Alzheimer
's
disease
(
AD
)
have
certain
clinical
and
histopathologic
features
in
common
;
both
are
characterized
by
cerebral
amyloid
beta
deposits
.
Extracellular
matrix
(
ECM
)
components
have
been
demonstrated
in
plaques
and
in
vascular
amyloid
of
AD
,
suggesting
a
causative
relation
.
We
studied
the
immunohistochemical
expression
of
the
ECM
components
collagen
type
I
,
III
,
and
IV
,
heparan
sulfate
proteoglycan
(
HSPG
)
,
laminin
,
and
fibronectin
in
cortical
tissue
of
six
HCHWA-D
patients
,
two
AD
patients
,
and
five
controls
.
The
vasculature
of
control
patients
and
the
noncongophilic
vessels
in
HCHWA-D
and
AD
patients
stained
for
all
ECM
components
,
with
the
exception
of
collagen
type
I
in
part
of
the
capillaries
.
The
media
of
normal
larger
vessels
stained
for
collagen
type
I
and
III
and
fibronectin
;
a
similar
pattern
was
found
in
the
vascular
amyloid
in
HCHWA-D
and
AD
patients
.
The
plaques
in
HCHWA-D
and
AD
reacted
for
HSPG
and
weakly
for
collagen
III
and
IV
and
laminin
.
Furthermore
,
with
the
exception
of
anti-collagen
type
I
,
all
anti-
ECM
Ab
decorated
coarse
deposits
clustered
in
the
vicinity
of
thick
-walled
,
amyloid-laden
vessels
in
HCHWA-D
patients
;
these
deposits
were
not
spatially
related
to
amyloid
beta
-
positive
plaques
.
This
study
demonstrates
the
presence
of
ECM
components
in
the
main
pathologic
features
of
HCHWA-D
and
as
perivascular
deposits
.
The
observed
distribution
of
matrix
molecules
is
partly
different
from
AD
.
The
ECM
may
well
be
essential
for
the
evolvement
of
the
pathology
of
HCHWA-D
.
Diseases
Validation
Diseases presenting
"cortical tissue"
symptom
familial hypocalciuric hypercalcemia
hereditary cerebral hemorrhage with amyloidosis
monosomy 21
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom