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Hereditary cerebral hemorrhage with amyloidosis-Dutch type: better correlation of cognitive deterioration with advancing age than with number of focal lesions or white matter hyperintensities.
[hereditary cerebral hemorrhage with amyloidosis]
The
relationship
between
cognitive
deterioration
and
abnormalities
detected
by
magnetic
resonance
imaging
(
MRI
)
was
investigated
to
determine
the
radiological
correlates
of
cognitive
deterioration
in
hereditary
cerebral
hemorrhage
with
amyloidosis
-
Dutch
type
(
HCHWA-D
)
.
Twenty
HCHWA-D
subjects
(
12
patients
who
had
suffered
one
or
more
strokes
and
eight
who
had
not
suffered
a
stroke
)
were
studied
with
MRI
and
underwent
extensive
neuropsychological
examination
.
On
MRI
the
number
of
focal
lesions
was
counted
,
and
white
matter
hyperintensities
(
WMHs
)
were
scored
semiquantitatively
.
A
significant
correlation
between
cognitive
deterioration
and
WMH
score
and
number
of
focal
lesions
was
found
.
However
,
cognitive
deterioration
,
WMH
score
,
and
the
number
of
focal
lesions
all
increase
with
age
,
and
therefore
their
mutual
correlation
can
be
explained
as
an
age
effect
.
This
study
shows
that
cognitive
deterioration
in
HCHWA-D
is
not
correlated
with
abnormalities
detected
by
MRI
(
number
of
focal
lesions
and
subcortical
WMHs
)
independently
of
age
.
Although
a
contribution
of
white
matter
changes
and
/
or
focal
lesions
,
possibly
in
combination
with
age
,
to
cognitive
deterioration
can
not
be
excluded
.
Cognitive
deterioration
in
these
HCHWA-D
patients
is
probably
primarily
the
result
of
chronic
damage
of
amyloid
angiopathy
to
the
brain
,
to
which
may
be
superimposed
cognitive
impairment
from
focal
cerebral
hemorrhage
or
infarction
.
Diseases
Validation
Diseases presenting
"abnormalities detected by magnetic resonance imaging"
symptom
hereditary cerebral hemorrhage with amyloidosis
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