Rare Diseases Symptoms Automatic Extraction

A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.

[hereditary cerebral hemorrhage with amyloidosis]

The cerebral deposition of 40-42 residue amyloid beta-protein (Abeta) is a characteristic of Alzheimer's disease. Cathepsin D is possibly involved in the intracellular clearance of Abeta (Hamazaki, H. (1996) FEBS Lett., in press). The present work shows that cathepsin D hydrolyzes wild-type Abeta 20 times faster than a variant Abeta with a substitution at residue 21 from Ala to Gly. Since the substitution has been linked to familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Hendriks et al. (1992) Nature Genet. 1, 218-221), the present observations suggest that the inefficient elimination of Abeta by cathepsin D is capable of being one of causes of the amyloid fibril formation.

Diseases presenting "amyloidosis" symptom

  • cadasil
  • fabry disease
  • familial mediterranean fever
  • hereditary cerebral hemorrhage with amyloidosis
  • lymphangioleiomyomatosis
  • phenylketonuria
  • systemic capillary leak syndrome
  • triple a syndrome
  • waldenström macroglobulinemia

This symptom has already been validated