Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells.
[hereditary cerebral hemorrhage with amyloidosis]
The
amyloid
beta
-protein
(
A
beta
)
pathologically
accumulates
in
cerebral
vascular
and
senile
plaque
deposits
in
the
brains
of
patients
with
Alzheimer
's
disease
(
AD
)
and
related
disorders
including
hereditary
cerebral
hemorrhage
with
amyloidosis
Dutch
type
(
HCHWA-D
)
.
The
cerebrovascular
deposits
are
accompanied
by
degeneration
and
eventual
loss
of
smooth
muscle
cells
in
cerebral
vessel
wall
.
Similarly
,
we
have
shown
that
pathogenic
forms
of
A
beta
cause
cell
death
in
cultured
human
cerebrovascular
smooth
muscle
(
HCSM
)
cells
in
vitro
.
Here
we
show
that
pathogenic
A
beta
induces
a
number
of
structural
changes
in
HCSM
cells
including
shrinkage
of
cell
bodies
,
retraction
of
processes
,
disruption
of
the
intracellular
actin
network
,
and
nuclear
condensation
and
fragmentation
.
These
changes
were
accompanied
by
a
number
of
biochemical
alterations
in
the
cells
shown
by
in
situ
end
labeling
of
nuclear
DNA
,
proteolytic
breakdown
of
smooth
muscle
cell
a
actin
,
and
proteolytic
activation
of
the
proteinase
caspase
3
.
Together
,
these
characteristics
are
consistent
with
an
apoptotic
mechanism
of
cell
death
in
HCSM
cells
in
response
to
pathogenic
A
beta
.
Diseases
Validation
Diseases presenting
"cerebral vessel wall"
symptom
hereditary cerebral hemorrhage with amyloidosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom