Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Ultrastructural evidence of early non-fibrillar Abeta42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type.
[hereditary cerebral hemorrhage with amyloidosis]
The
C-
terminal
profile
and
ultrastructure
of
small
and
presumably
early
capillary
amyloid
beta
protein
(
Abeta
)
deposits
were
investigated
in
four
patients
with
hereditary
cerebral
hemorrhage
with
amyloidosis
,
Dutch
type
.
The
C
terminus
of
the
40
(
Abeta
40
)
or
the
42
(
Abeta
42
)
amino
acid
form
of
Abeta
was
gold
labeled
in
serial
,
ultrathin
sections
on
glass
slides
for
reflection
contrast
microscopy
and
on
grids
for
electron
microscopy
.
In
all
studied
subjects
,
reflection
contrast
microscopy
revealed
capillaries
with
focal
Abeta
42
immunolabeling
in
the
absence
of
Abeta
40
labeling
.
In
the
adjacent
electron
microscopic
section
,
Abeta
42
labeling
was
confined
to
the
capillary
basement
membrane
.
The
majority
of
Abeta
42
(
+
)
40
(
-
)
deposits
showed
no
amyloid
fibrils
.
Abeta
42
(
+
)
40
(
-
)
deposits
were
sometimes
observed
in
an
unremarkable
basement
membrane
but
usually
showed
increased
electron
density
and
reticular
structures
.
A
small
subset
of
Abeta
42
(
+
)
40
(
-
)
deposits
with
basement
membrane
changes
showed
few
amyloid
fibrils
.
Abeta
42
(
+
)
40
(
+
)
capillary
deposits
always
showed
definite
fibrils
and
were
larger
than
Abeta
42
(
+
)
40
(
-
)
capillary
deposits
.
The
present
findings
suggest
that
in
capillaries
the
accumulation
and
subsequent
polymerization
of
Abeta
42
,
possibly
in
conjunction
with
basement
membrane
changes
,
precedes
the
definite
fibril
formation
with
Abeta
40
.
Diseases
Validation
Diseases presenting
"small subset"
symptom
child syndrome
cushing syndrome
hereditary cerebral hemorrhage with amyloidosis
hodgkin lymphoma, classical
primary effusion lymphoma
werner syndrome
zellweger syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom