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Neuroinflammation and Alzheimer disease: clinical and therapeutic implications.
[hereditary cerebral hemorrhage with amyloidosis]
In
Alzheimer
disease
brains
,
the
amyloid
plaques
are
closely
associated
with
a
locally
induced
,
nonimmune-mediated
,
chronic
inflammatory
response
without
any
apparent
influx
of
leukocytes
from
the
blood
.
The
present
findings
indicate
that
in
cerebral
A
beta
diseases
(
Alzheimer
disease
,
Down
syndrome
,
hereditary
cerebral
hemorrhage
with
amyloidosis
-
Dutch
type
)
,
the
clinical
symptoms
are
determined
to
a
great
extent
by
the
site
of
inflammatory
response
.
It
was
found
that
the
formation
of
the
amyloid-microglia
complex
seems
to
be
a
relatively
early
pathogenic
event
that
precedes
the
process
of
severe
destruction
of
the
neuropil
.
The
idea
that
inflammation
is
implicated
in
Alzheimer
pathology
has
received
support
from
the
epidemiologic
studies
indicating
that
the
use
of
anti-
inflammatory
drugs
can
prevent
or
retard
the
Alzheimer
disease
process
.
In
this
contribution
,
we
review
the
relationship
between
inflammation
and
clinical
manifestation
and
the
opportunities
for
anti-
inflammatory
treatments
in
Alzheimer
disease
.
Diseases
Validation
Diseases presenting
"nonimmune-mediated"
symptom
hereditary cerebral hemorrhage with amyloidosis
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