Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia.
[hereditary cerebral hemorrhage with amyloidosis]
Cerebral
amyloid
angiopathy
(
CAA
)
is
the
common
term
used
to
define
the
deposition
of
amyloid
in
the
walls
of
medium-
and
small
-size
leptomeningeal
and
cortical
arteries
,
arterioles
and
,
less
frequently
,
capillaries
and
veins
.
CAA
is
an
important
cause
of
cerebral
hemorrhages
although
it
may
also
lead
to
ischemic
infarction
and
dementia
.
It
is
a
feature
commonly
associated
with
normal
aging
,
Alzheimer
disease
(
AD
)
,
Down
syndrome
(
DS
)
,
and
Sporadic
Cerebral
Amyloid
Angiopathy
.
Familial
conditions
in
which
amyloid
is
chiefly
deposited
as
CAA
include
hereditary
cerebral
hemorrhage
with
amyloidosis
of
Icelandic
type
(
HCHWA
-
I
)
,
familial
CAA
related
to
Abeta
variants
,
including
hereditary
cerebral
hemorrhage
with
amyloidosis
of
Dutch
origin
(
HCHWA-D
)
,
the
transthyretin
-related
meningocerebrovascular
amyloidosis
of
Hungarian
and
Ohio
kindreds
,
the
gelsolin
-related
spinal
and
cerebral
amyloid
angiopathy
,
familial
PrP-CAA
,
and
the
recently
described
chromosome
13
familial
dementia
in
British
and
Danish
kindreds
.
This
review
focuses
on
the
various
molecules
and
genetic
variants
that
target
the
cerebral
vessel
walls
producing
clinical
features
related
to
stroke
and
/
or
dementia
,
and
discusses
the
potential
role
of
amyloid
in
the
mechanism
of
neurodegeneration
.
Diseases
Validation
Diseases presenting
"dementia"
symptom
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
carcinoma of the gallbladder
cushing syndrome
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
phenylketonuria
sneddon syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated