Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
[hereditary cerebral hemorrhage with amyloidosis]
The
vasculotropic
E
22
Q
mutant
of
the
amyloid-
beta
(
Abeta
)
peptide
is
associated
with
hereditary
cerebral
hemorrhage
with
amyloidosis
Dutch
type
.
The
cellular
mechanism
(
s
)
of
toxicity
and
nature
of
the
AbetaE
22
Q
toxic
assemblies
are
not
completely
understood
.
Comparative
assessment
of
structural
parameters
and
cell
death
mechanisms
elicited
in
primary
human
cerebral
endothelial
cells
by
AbetaE
22
Q
and
wild-
type
Abeta
revealed
that
only
AbetaE
22
Q
triggered
the
Bax
mitochondrial
pathway
of
apoptosis
.
AbetaE
22
Q
neither
matched
the
fast
oligomerization
kinetics
of
Abeta
42
nor
reached
its
predominant
beta
-sheet
structure
,
achieving
a
modest
degree
of
oligomerization
with
a
secondary
structure
that
remained
a
mixture
of
beta
and
random
conformations
.
The
endogenous
molecule
tauroursodeoxycholic
acid
(
TUDCA
)
was
a
strong
modulator
of
AbetaE
22
Q
-
triggered
apoptosis
but
did
not
significantly
change
the
secondary
structures
and
fibrillogenic
propensities
of
Abeta
peptides
.
These
data
dissociate
the
pro-apoptotic
properties
of
Abeta
peptides
from
their
distinct
mechanisms
of
aggregation
/
fibrillization
in
vitro
,
providing
new
perspectives
for
modulation
of
amyloid
toxicity
.
Diseases
Validation
Diseases presenting
"hereditary cerebral hemorrhage with amyloidosis dutch type"
symptom
hereditary cerebral hemorrhage with amyloidosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
