Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Isolation of amyloid by solubilization in water.
[hereditary cerebral hemorrhage with amyloidosis]
Amyloid
fibrils
are
highly
insoluble
in
neutral
aqueous
media
of
regular
ionic
strengths
making
solubilization
a
difficult
task
that
normally
calls
for
extremely
harsh
treatment
.
This
is
among
the
reasons
for
the
routine
employment
of
synthetic
proteins
in
amyloid
research
,
where
the
amylogenic
components
are
needed
.
Here
we
describe
a
process
for
solubilizing
amyloid
in
pure
water
that
we
adopted
from
a
method
developed
by
Mordechai
Pras
and
associates
.
We
have
used
it
for
solubilizing
cystatin
C
amyloid
and
extracting
it
out
of
leptomeningeal
tissue
and
skin
from
Hereditary
Cerebral
Hemorrhage
with
Amyloidosis
-
Icelandic
type
(
HCHWA
-
I
)
patients
.
HCHWA
-
I
is
a
rare
and
very
aggressive
heritable
form
of
cerebral
amyloid
angiopathy
(
CAA
)
-
specific
Icelandic
type
.
Similar
approach
has
been
employed
for
solubilization
of
different
forms
of
amyloid
from
other
organs
suggesting
broad
range
of
applicability
.
Diseases
Validation
Diseases presenting
"broad range"
symptom
acute rheumatic fever
congenital toxoplasmosis
cowden syndrome
cystinuria
dystrophic epidermolysis bullosa
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
kallmann syndrome
neuralgic amyotrophy
severe combined immunodeficiency
typhoid
waldenström macroglobulinemia
well-differentiated liposarcoma
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