Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Isolation of amyloid by solubilization in water.
[hereditary cerebral hemorrhage with amyloidosis]
Amyloid
fibrils
are
highly
insoluble
in
neutral
aqueous
media
of
regular
ionic
strengths
making
solubilization
a
difficult
task
that
normally
calls
for
extremely
harsh
treatment
.
This
is
among
the
reasons
for
the
routine
employment
of
synthetic
proteins
in
amyloid
research
,
where
the
amylogenic
components
are
needed
.
Here
we
describe
a
process
for
solubilizing
amyloid
in
pure
water
that
we
adopted
from
a
method
developed
by
Mordechai
Pras
and
associates
.
We
have
used
it
for
solubilizing
cystatin
C
amyloid
and
extracting
it
out
of
leptomeningeal
tissue
and
skin
from
Hereditary
Cerebral
Hemorrhage
with
Amyloidosis
-
Icelandic
type
(
HCHWA
-
I
)
patients
.
HCHWA
-
I
is
a
rare
and
very
aggressive
heritable
form
of
cerebral
amyloid
angiopathy
(
CAA
)
-
specific
Icelandic
type
.
Similar
approach
has
been
employed
for
solubilization
of
different
forms
of
amyloid
from
other
organs
suggesting
broad
range
of
applicability
.
