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Heparin-induced thrombocytopenia due to heparin lock in a hemodialysis patient: a case report.
[heparin-induced thrombocytopenia]
Heparin-induced
thrombocytopenia
(
HIT
)
is
a
potentially
fatal
clinical
condition
which
can
develop
after
exposure
to
unfractionated
or
low
-molecular-weight
heparins
.
Even
small
doses
of
heparin
such
as
heparin
flushes
in
hemodialysis
catheter
can
induce
the
development
of
HIT
.
However
,
the
true
incidence
of
heparin
lock-related
HIT
is
unknown
.
We
report
a
58
-
year
-old
woman
with
acute
kidney
injury
because
of
obstructive
uropathy
who
developed
HIT
after
heparin-free
hemodialysis
.
She
was
found
to
have
severe
thrombocytopenia
with
deep
vein
thrombosis
of
left
lower
limb
and
arterial
thrombosis
of
the
right
anterior
and
middle
cerebral
arteries
.
The
heparin-
platelet
factor
4
antibody
was
positive
and
she
was
put
on
plasmapharesis
.
However
,
her
condition
further
deteriorated
and
succumbed
shortly
.
Heparin
lock
solution
in
the
hemodialysis
catheter
was
believed
to
be
the
cause
of
HIT
in
our
patient
.
Diseases
Validation
Diseases presenting
"arterial thrombosis of the right anterior"
symptom
heparin-induced thrombocytopenia
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