Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Fondaparinux as a safe alternative for managing heparin-induced thrombocytopenia in postoperative cardiac surgery patients.
[heparin-induced thrombocytopenia]
Heparin-induced
thrombocytopenia
(
HIT
)
is
a
rare
but
severe
prothrombotic
disorder
of
heparin
treatment
that
leads
to
a
decline
in
platelet
count
and
thrombotic
complications
.
If
HIT
is
suspected
,
then
heparin
should
be
stopped
and
an
alternative
anticoagulant
started
.
Fondaparinux
is
a
factor
Xa-inhibitor
that
is
not
FDA-approved
for
this
condition
,
but
preliminary
experience
in
HIT
patients
has
been
reported
in
the
literature
.
The
present
study
describes
an
experience
of
anticoagulation
management
with
fondaparinux
in
postoperative
cardiac
surgery
patients
.
Retrospective
study
.
Tertiary
hospital
.
Patients
who
had
undergone
cardiac
surgery
from
October
2009
to
June
2012
.
After
HIT
was
suspected
clinically
,
PaGIA
and
ELISA
test
were
performed
in
all
patients
to
diagnose
HIT
.
In
the
patients
included
,
anticoagulation
was
managed
with
a
low
dose
of
fondaparinux
and
daily
monitoring
of
platelet
count
and
anti-
Xa
level
.
Of
a
total
of
1
,
338
postoperative
cardiac
surgery
patients
,
15
patients
were
included
(
1
.
1
%
)
.
Twelve
of
the
15
patients
with
HIT
presented
with
renal
failure
and
were
under
continuous
renal
replacement
therapy
.
Two
major
bleeding
events
occurred
during
fondaparinux
treatment
,
although
platelet
count
and
anti-
Xa
activity
remained
within
the
normal
range
.
No
thrombotic
episodes
were
diagnosed
.
With
daily
monitoring
of
anti-
Xa
activity
,
fondaparinux
appeared
to
be
a
good
alternative
to
heparin
in
the
study
group
;
however
,
randomized
clinical
trials
are
needed
to
establish
the
safety
and
efficacy
of
this
drug
in
critically
ill
,
previously
HIT
patients
.
Diseases
Validation
Diseases presenting
"anti-xa activity remained within the normal range"
symptom
heparin-induced thrombocytopenia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom