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A random Abstract
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The new direct oral anticoagulants in special indications: rationale and preliminary data in cancer, mechanical heart valves, anti-phospholipid syndrome, and heparin-induced thrombocytopenia and beyond.
[heparin-induced thrombocytopenia]
The
present
review
will
briefly
summarize
the
interplay
between
coagulation
and
inflammation
,
highlighting
possible
effects
of
direct
inhibition
of
factor
Xa
and
thrombin
beyond
anticoagulation
.
Additionally
,
the
rationale
for
the
use
of
the
new
direct
oral
anticoagulants
(
DOACs
)
for
indications
such
as
cancer
-associated
venous
thromboembolism
(
CAT
)
,
mechanical
heart
valves
,
thrombotic
anti-phospholipid
syndrome
(
APS
)
,
and
heparin-induced
thrombocytopenia
(
HIT
)
will
be
explored
.
Published
data
on
patients
with
cancer
or
mechanical
heart
valves
treated
with
DOAC
will
be
discussed
,
as
well
as
planned
studies
in
APS
and
HIT
.
Although
at
the
present
time
published
evidence
is
insufficient
for
recommending
DOAC
in
the
above-mentioned
indications
,
there
are
good
arguments
in
favor
of
clinical
trials
investigating
their
efficacy
in
these
contexts
.
Direct
inhibition
of
factor
Xa
or
thrombin
may
reveal
interesting
effects
beyond
anticoagulation
as
well
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated