Low prevalence of heparin-induced thrombocytopenia after cardiac surgery in Thai patients.

[heparin-induced thrombocytopenia]

Heparin induced-thrombocytopenia (HIT ) has been well recognized in Western countries . However , there are no data in the Thai population . We therefore investigated the prevalence of anti-platelet factor 4 (PF 4 )/heparin antibodies , HIT , and its thrombotic complications in Thai patients undergoing cardiac surgery using unfractionated heparin .Seventy -three consecutive patients were prospectively enrolled in this study . Blood samples before operation and week 1 , week 2 , and week 3 after operation were collected from each patient for HIT antibody screening by enzyme-linked immunosorbent assay using IgG antibody specific to the PF 4 /heparin complex . Positive samples were further analyzed by (14 )C-serotonin release assay . Complete blood count was performed daily during the first week , then weekly for 3 weeks .No patient had detectable anti-PF 4 /heparin antibodies at baseline . Five patients sero-converted during the course of the study for anti-PF 4 /heparin IgG : 3 (4 .1 %) at week 1 , 4 (5 .5 %) at week 2 , and 5 (6 .8 %) at week 3 after surgery . However , none of these patients had anti-PF 4 /heparin antibodies that resulted in (14 )C-serotonin release to be considered clinically significant antibodies . Post-operative thrombocytopenia after the operation was found in 35 patients (47 .9 %), but was not considered to be caused by HIT . Thromboembolic events occurred in 3 patients (4 .1 %) during follow up ; however , none of these patients had positive PF 4 /heparin antibody tests .Our study represents the first study to examine Thai patients exposed to heparin in the context of cardiac surgery . We found a lower prevalence of positive anti-PF 4 /heparin antibodies and clinical HIT than previously published studies .

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22q11.2 deletion syndrome

acute rheumatic fever

adrenomyeloneuropathy

alpha-thalassemia

aniridia

aromatase deficiency

benign recurrent intrahepatic cholestasis

canavan disease

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epidermolysis bullosa simplex

erdheim-chester disease

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familial mediterranean fever

heparin-induced thrombocytopenia

hirschsprung disease

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kallmann syndrome

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