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Familial ichthyosiform keratoderma in newly out-of-pouch Bennett's wallabies (Macropus rufogriseus) and report of two cases.
[harlequin ichthyosis]
Primary
inherited
disorders
of
cornification
in
veterinary
medicine
are
uncommon
and
rarely
reported
.
Herein
described
is
a
unique
syndrome
associated
with
keratoderma
that
occurred
in
two
Bennett
's
wallaby
siblings
(
Macropus
rufogriseus
)
,
and
was
characterized
by
profound
thickening
of
the
pad
skin
of
all
feet
,
generalized
scaling
of
haired
skin
,
and
death
within
7
weeks
of
out-of-pouch
experience
.
The
male
also
had
depressed
serum
zinc
levels
.
In
addition
,
the
male
had
,
on
electron
microscopic
exam
of
his
skin
,
the
presence
of
abnormal
lipid
deposits
within
the
stratum
corneum
and
stratum
granulosum
.
The
combination
of
clinical
features
and
electron
microscopic
findings
strongly
suggests
a
syndrome
analogous
to
harlequin
ichthyosis
or
lamellar
ichthyosis
in
humans
.
Diseases
Validation
Diseases presenting
"stratum granulosum"
symptom
harlequin ichthyosis
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