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Glyconanoparticle aided detection of β-amyloid by magnetic resonance imaging and attenuation of β-amyloid induced cytotoxicity.
[gm1 gangliosidosis]
The
development
of
a
noninvasive
method
for
the
detection
of
Alzheimer
's
disease
is
of
high
current
interest
,
which
can
be
critical
in
early
diagnosis
and
in
guiding
treatment
of
the
disease
.
The
aggregates
of
β-amyloid
are
a
pathological
hallmark
of
Alzheimer
's
disease
.
Carbohydrates
such
as
gangliosides
have
been
shown
to
play
significant
roles
in
initiation
of
amyloid
aggregation
.
Herein
,
we
report
a
biomimetic
approach
using
superparamagnetic
iron
oxide
glyconanoparticles
to
detect
β-amyloid
.
The
bindings
of
β-amyloid
by
the
glyconanoparticles
were
demonstrated
through
several
techniques
including
enzyme
linked
immunosorbent
assay
,
gel
electrophoresis
,
tyrosine
fluorescence
assay
,
and
transmission
electron
microscopy
.
The
superparamagnetic
nature
of
the
nanoparticles
allowed
easy
detection
of
β-amyloid
both
in
vitro
and
ex
vivo
by
magnetic
resonance
imaging
.
Furthermore
,
the
glyconanoparticles
not
only
were
nontoxic
to
SH-
SY
5
Y
neuroblastoma
cells
but
also
greatly
reduced
β-amyloid
induced
cytotoxicity
to
cells
,
highlighting
the
potential
of
these
nanoparticles
for
detection
and
imaging
of
β-amyloid
.
